Growing evidence suggests that human cancers are stem cell diseases and recent data support the existence of cancer stem cells (CSCs) in a variety of malignancies, including colon cancer. The study population consisted of 222 patients with pancreaticobiliary cancer aged over 70 years. The patients were divided into two groups: 192 patients as septuagenarians and 30 as octogenarians.
The purpose of the present study was to assess the impact of single-nucleotide polymorphisms (SNPs) in stem cell-related genes on clinical outcome in a large cohort of colon cancer patients with clinical stage II and III.
Germline variants rs13347 and rs187115 in the stem cell gene CD44 are prognostically relevant in stage II and III colon cancer patients. To clarify risk factors and long-term progress of postoperative recurrent laryngeal nerve paralysis (PRNP) in patients with esophageal cancer. One hundred and twenty-five esophageal cancer patients, who underwent subtotal esophagetomy, including recurrent laryngeal nerve lymphadenectomy, were analyzed. A laryngoscopy was routinely performed to assess the motility of vocal cords. The long-term follow-up of vocal cords was necessary to detect patients with either transient or permanent PRNP.
Complete resection, surgical expertise and individualization of patient management in comprehensive oncology centres result in better clinical outcomes in patients presenting with retroperitoneal sarcomas. A second primary malignancy is a serious long-term complication in cancer survivors. The aim of this study was to evaluate the risk of second primary malignancies (SPM) in adult patients with bladder cancer.
Clinical outcomes of primary and recurrent retroperitoneal sarcoma resections performed between January 2002 and December 2016 in two large surgical oncology, but non-sarcoma specialist centers, were reviewed to determine the efficacy of complete surgical resection as the principle instrument for treatment.
The histological type, tumor size and grade, as well as organ resection, were recorded and subsequently reviewed. Complete surgical resection of retroperitoneal sarcomas combined with individualized patient management when offered by experienced surgical oncology teams, adhering to international guidelines, can succeed in providing patients with good long-term outcomes, comparable to those achieved at sarcoma-specialist centers.
There is significant increased risk of second primary malignancies in adult patients with bladder cancer to general population. Postoperative morbidity and long-term outcome were compared between the two groups, and prognostic factors relating to survival time were identified.
Bladder cancer survivors may benefit from life-long follow-up for development of SPM. Pancreaticoduodenectomy (PD) treatment outcomes in elderly patients have been reported to be acceptable, but the eligibility criteria are not clear. These five eligibility criteria for PD in elderly patients are also satisfactorily applicable to octogenarian patients. These criteria may be helpful when uncertainties arise regarding the selection of PD.
To elucidate the importance of PD in octogenarians in particular, we set five eligibility criteria for elderly patients based on preoperative cardiac and pulmonary function, nutritional status, daily activity status, and psychological independence status for the first time and evaluated prospectively whether the validity of patient selection was adaptable.
To report the outcomes of salvage robot-assisted radical prostatectomy (S-RaRP). The mean initial prostatic-specific antigen level was 14.3 ng/ml and mean Gleason score was 6.93. Initial definitive treatment was external irradiation in 11 cases, cyberknife in two, and high-intensity focused ultrasound in one. Time from definitive treatment to S-RaRP was a mean of 36.5 months. S-RaRP is feasible with a low complication rate, good continence rate, and an acceptable potency rate.